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Complete List of Published Work in My Bibliography    

Publications from 2017-present:

1.         Chen, T., Huang, Z., Liu, R., Yang, J., Hylemon, P. B., and Zhou, H. (2017) Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. Frontiers in bioscience (Landmark edition) 22, 596-608

2.         Kang, D. J., Hylemon, P. B., Gillevet, P. M., Sartor, R. B., Betrapally, N. S., Kakiyama, G., Sikaroodi, M., Takei, H., Nittono, H., Zhou, H., Pandak, W. M., Yang, J., Jiao, C., Li, X., Lippman, H. R., Heuman, D. M., and Bajaj, J. S. (2017) Gut microbial composition can differentially regulate bile acid synthesis in humanized mice. Hepatology communications 1, 61-70

3.         Kwong, E. K., Li, X., Hylemon, P. B., and Zhou, H. (2017) Sphingosine Kinases/Sphingosine 1-Phosphate Signaling in Hepatic Lipid Metabolism. Current pharmacology reports 3, 176-183.

4.         Li, X., Liu, R., Luo, L., Yu, L., Chen, X., Sun, L., Wang, T., Hylemon, P. B., Zhou, H., Jiang, Z., and Zhang, L. (2017) Role of AMP-activated protein kinase alpha1 in 17alpha-ethinylestradiol-induced cholestasis in rats. Archives of Toxicology 91, 481-494.

5.         Li, X., Liu, R., Yang, J., Sun, L., Zhang, L., Jiang, Z., Puri, P., Gurley, E. C., Lai, G., Tang, Y., Huang, Z., Pandak, W. M., Hylemon, P. B., and Zhou, H. (2017) The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice. Hepatology 66, 869-884.

6.         Puri, P., Daita, K., Joyce, A., Mirshahi, F., Santhekadur, P. K., Cazanave, S., Luketic, V. A., Siddiqui, M. S., Boyett, S., Min, H. K., Kumar, D. P., Kohli, R., Zhou, H., Hylemon, P. B., Contos, M. J., Idowu, M., and Sanyal, A. J. (2017) The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids. Hepatology.

7.         Qu, C., Wang, L. Y., Lin, H., Shang, E. X., Tang, Y. P., Yue, S. J., Jin, Y., Tao, W. W., Li, S. P., Hua, Y. Q., Liu, P., Su, S. L., Zhou, H., Qian, D. W., and Duan, J. A. (2017) Hierarchical identification of bioactive components in a medicinal herb by preparative high-performance liquid chromatography and selective knock-out strategy. Journal of pharmaceutical and biomedical analysis 135, 206-216.

8.         Shen, J., Pu, Z. J., Kai, J., Kang, A., Tang, Y. P., Shang, L. L., Zhou, G. S., Zhu, Z. H., Shang, E. X., Li, S. P., Cao, Y. J., Tao, W. W., Su, S. L., Zhang, L., Zhou, H., Qian, D. W., and Duan, J. A. (2017) Comparative metabolomics analysis for the compatibility and incompatibility of kansui and licorice with different ratios by UHPLC-QTOF/MS and multivariate data analysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 1057, 40-45.

9.         Wang, Y., Aoki, H., Yang, J., Peng, K., Liu, R., Li, X., Qiang, X., Sun, L., Gurley, E. C., Lai, G., Zhang, L., Liang, G., Nagahashi, M., Takabe, K., Pandak, W. M., Hylemon, P. B., and Zhou, H. (2017) The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. Hepatology 65, 2005-2018.

10.       Yang, J., Li, Y. Z., Hylemon, P. B., Zhang, L. Y., and Zhou, H. P. (2017) Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 95, 1777-1788.

11.       Zhang, J., Feng, Z., Wang, C., Zhou, H., Liu, W., Kanchana, K., Dai, X., Zou, P., Gu, J., Cai, L., and Liang, G. (2017) Curcumin derivative WZ35 efficiently suppresses colon cancer progression through inducing ROS production and ER stress-dependent apoptosis. American journal of cancer research 7, 275-288.

12.       Ge, Y. H., Chen, Y. Y., Zhou, G. S., Liu, X., Tang, Y. P., Liu, R., Liu, P., Li, N., Yang, J., Wang, J., Yue, S. J., Zhou, H., and Duan, J. A. (2018) A Novel Antithrombotic Protease from Marine Worm Sipunculus Nudus. International journal of molecular sciences 19.

13.       Li, X., Liu, R., Huang, Z., Gurley, E. C., Wang, X., Wang, J., He, H., Yang, H., Lai, G., Zhang, L., Bajaj, J. S., White, M., Pandak, W. M., Hylemon, P. B., and Zhou, H. (2018) Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans. Hepatology 68, 599-615.

14.       Liu, R., Li, X., Huang, Z., Zhao, D., Ganesh, B. S., Lai, G., Pandak, W. M., Hylemon, P. B., Bajaj, J. S., Sanyal, A. J., and Zhou, H. (2018) C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice. Hepatology 67, 1441-1457.

15.       Liu, R., Li, X., Hylemon, P. B., and Zhou, H. (2018) Conjugated Bile Acids Promote Invasive Growth of Esophageal Adenocarcinoma Cells and Cancer Stem Cell Expansion via Sphingosine 1-Phosphate Receptor 2-Mediated Yes-Associated Protein Activation. The American journal of pathology 188, 2042-2058.

16.       Wan, X. S., Wang, X., Xiao, J., Li, X. K., and Zhou, H. (2018) Corrigendum to "ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress". BioMed research international 2018, 3218606.

17.       Zhou, D., Chen, Y. W., Zhao, Z. H., Yang, R. X., Xin, F. Z., Liu, X. L., Pan, Q., Zhou, H., and Fan, J. G. (2018) Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression. Experimental & molecular medicine 50, 157.

18.       Chen, X., Chen, X., Zhang, X., Wang, L., Cao, P., Rajamanickam, V., Wu, C., Zhou, H., Cai, Y., Liang, G., and Wang, Y. (2019) Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells. Redox biology 21, 101061.

19.       Chen, Y. Y., Tang, Y. P., Shang, E. X., Zhu, Z. H., Tao, W. W., Yu, J. G., Feng, L. M., Yang, J., Wang, J., Su, S. L., Zhou, H., and Duan, J. A. (2019) Incompatibility assessment of Genkwa Flos and Glycyrrhizae Radix et Rhizoma with biochemical, histopathological and metabonomic approach. Journal of Ethnopharmacology 229, 222-232.

20.       Kakiyama, G., Marques, D., Takei, H., Nittono, H., Erickson, S., Fuchs, M., Rodriguez-Agudo, D., Gil, G., Hylemon, P. B., Zhou, H., Bajaj, J. S., and Pandak, W. M. (2019) Mitochondrial oxysterol biosynthetic pathway gives evidence for CYP7B1 as controller of regulatory oxysterols. The Journal of steroid biochemistry and molecular biology 189:36-47.

21.       Kang, J. D., Myers, C. J., Harris, S. C., Kakiyama, G., Lee, I. K., Yun, B. S., Matsuzaki, K., Furukawa, M., Min, H. K., Bajaj, J. S., Zhou, H., and Hylemon, P. B. (2019) Bile Acid 7alpha-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids. Cell chemical biology 26, 27-34 e24.

22.       Liu, R., Ahluwalia, V., Kang, J. D., Ghosh, S. S., Zhou, H., Li, Y., Zhao, D., Gurley, E., Li, X., White, M. B., Fagan, A., Lippman, H. R., Wade, J. B., Hylemon, P. B., and Bajaj, J. S. (2019) Effect of Increasing Age on Brain Dysfunction in Cirrhosis. Hepatology communications 3, 63-73. PMID: 30619995.

23.       Yi, H., Xu, D., Wu, X., Xu, F., Lin, L., and Zhou, H. (2019) Isosteviol Protects Free Fatty Acid- and High Fat Diet-Induced Hepatic Injury via Modulating PKC-beta/p66Shc/ROS and Endoplasmic Reticulum Stress Pathways. Antioxidants & redox signaling. 2019;30 (17):1949-1968. PMID: 30484323.

24.       Kwong EK, Liu R, Zhao D, Li X, Zhu W, Wang X, Gurley EC, Lai G, Liu J, Hylemon PB, Zhou H. The role of sphingosine kinase 2 in alcoholic liver disease. Dig Liver Dis. 2019 Apr 16; doi: 10.1016/j.dld.2019.03.020. [Epub ahead of print] PubMed PMID: 31003959.

25.       Liu R, Li X, Zhu W, Wang Y, Zhao D, Wang X, Gurley EC, Liang G, Chen W, Lai G, Pandak WM, Robert Lippman H, Bajaj JS, Hylemon PB, Zhou H. Cholangiocyte-Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis. Hepatology 2019 Apr 15 doi:10.1002/hep.30662. [Epub ahead of print]. PMID 30985008.

26.       Xiao Y, Liu R, Li X, Gurley EC, Hylemon PB, Lu Y, Zhou H, and Cai W. Long non-coding RNA H19 contributes to cholangiocyte proliferation and cholestatic liver fibrosis in biliary atresia. Hepatology, 2019. May 7. doi: 10.1002/hep.30698. [Epub ahead of print]. PMID: 31063660.

27.       Liu R, Kang JD, Sartor RB, Sikaroodi M, Fagan A, Gavis EA, Zhou H, Hylemon PB, Herzog JW, Li X, Lippman RH, Maeso JG, Wade JB, Ghosh S, Gurley E, Gillevet PM, Bajaj JS Neuroinflammation in Murine Cirrhosis is Dependent on the Gut Microbiome and is Attenuated by Fecal Transplant. Hepatology, 2019 2019 Jun 20. doi: 10.1002 /hep.30827.

[Epub ahead of print]. PMID:31220352.


Huiping Zhou, Ph.D., AGAF, FAASLD


Department of Microbiology and Immunology

Medical College of Virginia

Virginia Commonwealth University 

Research Career Scientist

McGuire VA Medical Center

Richmond, VA




Kontos Medical Sciences Building

Room 534, 511, 515

1217 E Marshall Street

Richmond, VA 23298​

Tel:804-827-1556 or 804-828-2332

McGuire VA Medical Center


1201 Broad Rock Blvd

Richmond, VA 23249-0001



Molecular Medicine Research Building

Room 5-044

1220 E Broad Street, Richmond VA 23298

Tel: 804-828-6817

McGuire VA Medical Center


1201 Broad Rock Blvd

Richmond, VA 23249-0001

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